CATARANTHUS ROSEUS ISHLAB CHIQARILADIGAN VINBLASTIN MODDASINI SINTEZLASHDA ZCT GEN OILASI TA'SIRI
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Abstract
Cataranthus roseus (Madagaskar pervinkasi) o'simligi tibbiyotda qimmatbaho dori moddalarini ishlab chiqarish uchun asosiy xom ashyo hisoblanadi. Uning tarkibida vinblastin va vinkristin kabi monoterpenoid indol alkaloidlari (MIA) mavjud bo‘lib, ular saraton kasalligini davolashda ishlatiladi. Vinblastin – tabiatda kam uchraydigan va murakkab biosintetik jarayon orqali hosil qilinadigan moddadir. Ushbu jarayonda ZCT (Zinc finger Catharanthus transcription factor) gen oilasi muhim rol o‘ynaydi. Mazkur tezisda vinblastin sintezining molekulyar mexanizmlari va ZCT gen oilasining unga ta’siri tahlil qilinadi.
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Cole-Osborn LF, Meehan E, Lee-Parsons CWT.Plant Direct. 2024 Jun 5;8(6):e596. doi: 10.1002/pld3.596. eCollection 2024 Jun.PMID: 38855128 Free PMC article.
Li CY, Gibson SI. PeerJ. 2021 Jul 2;9: e11624. doi: 10.7717/peerj.11624. eCollection 2021.PMID: 34249496 Free PMC article.
Lopez C, Claude B, Morin P, Max JP, Pena R, Ribet JP. Anal Chim Acta. 2011 Jan 10;683(2):198-205. doi: 10.1016/j.aca.2010.09.051. Epub 2010 Oct 7. PMID: 21167971
Zheng Z, Wu M (2004) Cadmium treatment enhances the production of alkaloid secondary metabolites in Catharanthus roseus. Plant Sci 166:507–514
Fahy J, Hellier P, Breillout F, Bailly C. Semin Oncol. 2008 Jun;35(3 Suppl 3): S3-5. doi: 10.1053/j.seminoncol.2008.01.004.PMID: 18538177 8