CTLA-4 GENI POLIMORFIZMILARI VA QANDLI DIABETNI ERTA TASHXISLASH

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Published: 2025-03-29
DOI: https://doi.org/10.5281/
Keywords:
CTLA-4, 1TQD, PCR, polimorfizm, autoimmune, Tlymphocyte

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Saidov Z.U.
O‘zbekiston Milliy unversitetining Jizzax filiali Biofizika va biokimyo instituti
Mustafakulov M.A.
O‘zbekiston Milliy unversitetining Jizzax filiali Biofizika va biokimyo instituti

Abstract

1-turdagi qandli diabet (1TQD) insulin ishlab chiqaruvchi beta hujayralarining yo‘qolishi bilan yuzaga keladigan autoimmun kasallikdir. 1TQD rivojlanishiga genetik va atrof-muhit omillari ta'sir qiladi, bunda immun tizimining noto‘g‘ri ishlashi muhim rol o‘ynaydi. CTLA-4 geni immun tizimining faoliyatini boshqarib, autoimmun kasalliklar, jumladan 1TQDda ham ishtirok etadi. CTLA-4 polimorfizmlari immun tizimidagi o‘zgarishlarga olib kelib, kasallikning rivojlanishiga ta'sir ko‘rsatishi mumkin. Ushbu tadqiqotlar natijasida CTLA-4 polimorfizmlarining autoimmun kasalliklar, ayniqsa, 1-turdagi qandli diabetning rivojlanishidagi o‘rni va ahamiyati to‘g‘risida chuqurroq tushunchaga ega bo‘lish mumkin. CTLA-4 polimorfizmlarining diagnostik marker sifatida ishlatilishi, 27 qandli diabetni erta aniqlash va kasallikning oldini olish uchun yangi yondashuvlarni ishlab chiqishga yordam beradi. Shuningdek, genetik tahlil usullari, masalan, PCR va sekvenatsiya texnologiyalari, CTLA-4 polimorfizmlarini aniqlash va tahlil qilishda samarali qo‘llaniladi, bu esa genetik asosli tashxislashning aniqligini oshiradi.

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Vol. 1 No. 1 (2025): BIOTEXNOLOGIYANING RIVOJLANISH ISTIQBOLLARI VA MUAMMOLARI RЕSPUBLIKA ILMIY ANJUMANI, 28-29 mart 2025 y

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Saidov, Z., & Mustafakulov, M. (2025). CTLA-4 GENI POLIMORFIZMILARI VA QANDLI DIABETNI ERTA TASHXISLASH. Konferensiyalar, 1(1), 27-29. https://doi.org/10.5281/

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